developmental toxicityの例文

• Last is the developmental toxicity that can occur as an organism grows.
• Animal studies have found no evidence for carcinogenicity or developmental toxicity.
• Exposure to high levels of chlormequat has been linked to developmental toxicity in animal models.
• Sunset Yellow FCF has no carcinogenicity, genotoxicity, or developmental toxicity in the amounts at which it is used.
• Early in Holson's career, while at NCTR, he led studies that assessed the developmental toxicity of fetal histopathology and teratological evaluation.
• It includes adverse effects on sexual function and fertility in adult males and females, as well as developmental toxicity in the offspring.
• Developmental toxicity looks at the impact the nanoparticle has on the growth of an organism from an embryonic stage to a later set point.
• At the high dose, definitive evidence of developmental toxicity was limited to a statistically significant ( ~ 8 % ) reduction in average fetal body weight per litter ."
• While further toxicological assessments, including chronic ( repeated dose ), reproductive, and developmental toxicity studies, are still needed, yet the present results strongly suggest that as-grown SWNHs have low acute toxicities.
• Effective April 1, 1990, the Office of Environmental Health Hazard Assessment ( OEHHA ) of the California Environmental Protection Agency added nicotine to the list of chemicals known to cause developmental toxicity.
• It is not listed for reproductive or developmental toxicity, but is listed on EPA's Tier 1 Screening Order for chemicals to be tested under the Endocrine Disruptor Screening Program ( EDSP ).
• According to boric acid IUCLID Dataset published by the European Commission, boric acid in high doses shows significant developmental toxicity and teratogenicity in rabbit, rat, and mouse fetuses as well as cardiovascular defects, skeletal variations, mild kidney lesions.
• Throughout his career Holson argued consistently that developmental toxicity must be viewed holistically, not simply as a group of disparate anatomical, functional, and postnatal defects, before such data can be effectively used to derive a complete estimate of human risks.
• Dr . Andrew Olshan, an assistant professor of epidemiology at the University of North Carolina School of Public Health, cautioned that there is no smoking gun-- no straight line between fathers'occupational exposures and what he calls " developmental toxicity ."
• They may be at risk " for a number of adverse effects including developmental toxicity, reduced reproductive capacity in males based on decreased sperm counts, higher probability of experiencing endometriosis in women, reduced ability to withstand immunological challenge and others ."
• Researchers from Korea state that : " DEHT, a phthalate ester stoichiometrically eqivaluent to DEHP, has been shown to have potential reproductive and developmental toxicity . " It should be noted that the NOAELs quoted are actually quite high, indicating the potential for reproductive toxicity is low.
• According to an analysis conducted by the Environmental Working Group of contaminants which have an established method of detection, and were monitored in water supplies between 2004 and 2008, 168 have been linked to cancer, 54 to reproductive toxicity, 67 to developmental toxicity, and 35 to immune system damage.
• There was no definitive evidence of developmental toxicity in this study . " Another study, where mice were fed ~ 300 times the estimated human intake from dietary supplements, concluded, " Maternal liver weights were increased at greater than 12, 500 ppm, but in the absence of treatment-related histopathological lesions.
• Based on his early work, Holson was among the first teratology researchers to assert that the various endpoints of developmental toxicity studies ( intrauterine growth retardation, malformations [ birth defects ], functional impairment, and death ) in fact constituted a continuum of responses rather than discrete outcomes, which led him to conclude that human manifestations of teratogenicity across exposure levels were most commonly multiple outcomes.